Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1K6Q4)

• DTT Name: Arylamine N-acetyltransferase (NAT)
• Synonyms: NAT; N-acetyltransferase; Arylamide acetylase; AAC
• Gene Name: NAT1
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Acyltransferase
• UniProt ID: ARY1_HUMAN ; ARY2_HUMAN
• TTD ID: T49995
• Sequence:
  MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVV
  RRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYI
  VDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDL
  LEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLT
  HRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
• Function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid.
• KEGG Pathway:
  Caffeine metabolism (hsa00232)
  Drug metabolism - other enzymes (hsa00983)
  Metabolic pathways (hsa01100)
  Chemical carcinogenesis - DNA adducts (hsa05204)
• Reactome Pathway:
  Paracetamol ADME (R-HSA-9753281)
  Acetylation (R-HSA-156582)

Molecular Interaction Atlas (MIA) of This DTT

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(Z)-5-Benzylidene-2-thioxothiazolidin-4-one	DM3ALJD	Discovery agent	N.A.	Investigative	[1]
(Z)-5-Butylidene-2-thioxothiazolidin-4-one	DMLRWAF	Discovery agent	N.A.	Investigative	[1]
(Z)-5-Decylidene-2-thioxothiazolidin-4-one	DM5U1M8	Discovery agent	N.A.	Investigative	[1]
(Z)-5-Hexylidene-2-thioxothiazolidin-4-one	DMV70YA	Discovery agent	N.A.	Investigative	[1]
(Z)-5-Octylidene-2-thioxothiazolidin-4-one	DMEJNFS	Discovery agent	N.A.	Investigative	[1]

References

• [1] Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse a... Bioorg Med Chem. 2009 Jan 15;17(2):905-18.