Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1KS9D)

• DTT Name: Pleckstrin homology-like domain B 3 (PHLDB3)
• Synonyms: Pleckstrin homology-like domain family B member 3
• Gene Name: PHLDB3
• DTT Type: Literature-reported target; [1]
• UniProt ID: PHLB3_HUMAN
• TTD ID: T43778
• Sequence:
  MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVG
  EGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVK
  ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ
  RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ
  LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAE
  SRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQ
  DAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLE
  ASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREGTR
  RGTEGSSGPAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLV
  KMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNP
  RLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP
• Function: Binds to MDM2 and facilitates MDM2-mediated ubiquitination and degradation of p53. Promotes cell growth and inhibits apoptosis. Plays an oncogenic role by in part inhibiting p53 activity in a feedback fashion.

References

• [1] Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. Nat Commun. 2016 Dec 23;7:13755.