Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1NLOA)

DTT Name	P2X purinoceptor 4 (P2RX4)
Synonyms	P2X4; P2RX4
Gene Name	P2RX4
DTT Type	Clinical trial target	[1]
BioChemical Class	ATP-gated P2X receptor cation channel
UniProt ID	P2RX4_HUMAN
TTD ID	T60330
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC MKKRLYYREKKYKYVEDYEQGLASELDQ
Function	Receptor for ATP that acts as a ligand gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
KEGG Pathway	Calcium signaling pathway (hsa04020 ) Neuroactive ligand-receptor interaction (hsa04080 )
Reactome Pathway	Platelet homeostasis (R-HSA-418346 ) Purinergic signaling in leishmaniasis infection (R-HSA-9660826 ) Elevation of cytosolic Ca2+ levels (R-HSA-139853 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MRS-2160	DMHJ47A	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------

References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	Purine and pyrimidine (P2) receptors as drug targets. J Med Chem. 2002 Sep 12;45(19):4057-93.