Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1OPCB)

• DTT Name: Caspase-6 (CASP6)
• Synonyms: MCH2; Caspase-6 subunit p18; Caspase-6 subunit p11; CASP-6; Apoptotic protease Mch-2
• Gene Name: CASP6
• DTT Type: Patented-recorded target; [1]
• BioChemical Class: Peptidase
• UniProt ID: CASP6_HUMAN
• TTD ID: T20600
• EC Number: EC 3.4.22.59
• Sequence:
  MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLT
  LPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLS
  HGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDN
  QTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYG
  SSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
• Function: Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Involved in the activation cascade of caspases responsible for apoptosis execution.
• KEGG Pathway: Apoptosis (hsa04210)
• Reactome Pathway:
  Caspase-mediated cleavage of cytoskeletal proteins (R-HSA-264870)
  Breakdown of the nuclear lamina (R-HSA-352238)
  TP53 Regulates Transcription of Caspase Activators and Caspases (R-HSA-6803207)
  Apoptotic cleavage of cellular proteins (R-HSA-111465)

References

• [1] Caspase inhibitors: a review of recently patented compounds (2013-2015).Expert Opin Ther Pat. 2018 Jan;28(1):47-59.