Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1VNCG)

• DTT Name: Protein-cysteine N-palmitoyltransferase HHAT (HHAT)
• Synonyms: Skinny hedgehog protein 1; Melanoma antigen recognized by T-cells 2; MART-2; Hedgehog acyltransferase; HHAT
• Gene Name: HHAT
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Acyltransferase
• UniProt ID: HHAT_HUMAN
• TTD ID: T01725
• EC Number: EC 2.3.1.-
• Sequence:
  MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEW
  SFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLH
  TTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYY
  TSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKAS
  LCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKY
  LVLFGVPALLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHG
  LLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFS
  PQARRRFHAALASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGWPWVTLSVLGFLYCYS
  HVGIAWAQTYATD
• Function: Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP. .
• KEGG Pathway: Hedgehog signaling pathway (hsa04340)
• Reactome Pathway:
  HHAT G278V doesn't palmitoylate Hh-Np (R-HSA-5658034)
  Hedgehog ligand biogenesis (R-HSA-5358346)

References

• [1] Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2015 Jan 8;34(2):263-8.