Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1YE9Z)

DTT Name	Solute carrier family 38 member 1 (SLC38A1)
Synonyms	System N amino acid transporter 1; System A amino acid transporter 1; Sodium-coupled neutral amino acid transporter 1; SNAT1; SAT1; NAT2; N-system amino acid transporter 2; Amino acid transporter A1; ATA1
Gene Name	SLC38A1
DTT Type	Literature-reported target	[1]
UniProt ID	S38A1_HUMAN
TTD ID	T30844
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEK KKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSIN LLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFL MGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKK FQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELK DRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAV IVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGV VGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACS SSSDEGH
Function	Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
KEGG Pathway	Glutamatergic synapse (hsa04724 ) GABAergic synapse (hsa04727 )
Reactome Pathway	Amino acid transport across the plasma membrane (R-HSA-352230 ) Astrocytic Glutamate-Glutamine Uptake And Metabolism (R-HSA-210455 )

The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Sodium-coupled neutral amino acid transporter 1 (SLC38A1) DTP Info

Gene Name

SLC38A1

2 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[2]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[2]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1169).
2	Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11.