Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT2A1DZ)

• DTT Name: Solute carrier family 19 member 2 (SLC19A2)
• Synonyms: Thiamine transporter 1; Thiamine carrier 1; ThTr1; ThTr-1; TRMA; THT1; TC1
• Gene Name: SLC19A2
• DTT Type: Literature-reported target; [1]
• UniProt ID: S19A2_HUMAN
• TTD ID: T95997
• Sequence:
  MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
  DKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQG
  LLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILV
  SVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
  TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSV
  WWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWST
  WGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERY
  ALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
  KCRKLEDPQSSSQVTTS
• Function: High-affinity transporter for the intake of thiamine.
• KEGG Pathway: Vitamin digestion and absorption (hsa04977)
• Reactome Pathway: Vitamin B1 (thiamin) metabolism (R-HSA-196819)

Molecular Interaction Atlas (MIA) of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[3H]thiamine	DMSHW2E	Hyperemesis gravidarum		Investigative	[1]

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Thiamine transporter 1 (SLC19A2) DTP Info
• Gene Name: SLC19A2

1 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metformin	DM89QE1	Colorectal carcinoma		Approved	[2]

References

• [1] Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem. 1999 Nov 5;274(45):31925-9.
• [2] Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7;12(12):4301-10.