| DTT Name |
HUMAN vacuolar-type proton ATPase catalytic A (v-ATPase-A)
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| Synonyms |
Vacuolar proton pump subunit alpha; Vacuolar ATPase isoform VA68; VPP2; V-ATPase subunit A; V-ATPase 69 kDa subunit; ATP6V1A1; ATP6V1A; ATP6A1 |
| Gene Name |
ATP6V1A
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| BioChemical Class |
Acid anhydrides hydrolase
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| EC Number |
EC 7.1.2.2
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| Sequence |
MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGD
MATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPR
GVNVSALSRDIKWDFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIA
PPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPC
VQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDG
KVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALRE
ISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVSIVGAVSPPGGDFSDP
VTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYMRALDEYYDKHFTEFVPLRTKAK
EILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGM
LSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKDPLKDGEAKIKSD
YAQLLEDMQNAFRSLED
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| Function |
Human protein ATPase H+ transporting V1 subunit A interacts with SARS-CoV-2 M protein with high significance, which indicates ATP6V1A as a potential therapeutic target. |
| KEGG Pathway |
- Oxidative phosphorylation (hsa00190 )
- Metabolic pathways (hsa01100 )
- Phagosome (hsa04145 )
- mTOR signaling pathway (hsa04150 )
- Synaptic vesicle cycle (hsa04721 )
- Collecting duct acid secretion (hsa04966 )
- Vibrio cholerae infection (hsa05110 )
- Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
- Human papillomavirus infection (hsa05165 )
- Rheumatoid arthritis (hsa05323 )
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| Reactome Pathway |
- Insulin receptor recycling (R-HSA-77387 )
- Transferrin endocytosis and recycling (R-HSA-917977 )
- Amino acids regulate mTORC1 (R-HSA-9639288 )
- Ion channel transport (R-HSA-983712 )
- ROS and RNS production in phagocytes (R-HSA-1222556 )
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| BioCyc Pathway |
- MetaCyc:HS03781-MON
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