Details of the Drug Therapeutic Target (DTT)
General Information of Drug Therapeutic Target (DTT) (ID: TT2SRE0)
| DTT Name | Caspase-activated deoxyribonuclease (DFFB) | ||||
|---|---|---|---|---|---|
| Synonyms | DFFB; DFF-40; Caspase-activated nuclease; Caspase-activated DNase; CPAN | ||||
| Gene Name | DFFB | ||||
| DTT Type |
Literature-reported target
|
[1] | |||
| UniProt ID | |||||
| TTD ID | |||||
| 3D Structure | |||||
| EC Number |
EC 3.-.-.-
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| Sequence |
MLQKPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTEDYF
PSVPDNAELVLLTLGQAWQGYVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQRQRLLA DLLHNVSQNIAAETRAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSYPSTVGA EAQEEFLRVLGSMCQRLRSMQYNGSYFDRGAKGGSRLCTPEGWFSCQGPFDMDSCLSRHS INPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAIKEQDGREVDWEYFYGLLFTSENLK LVHIVCHKKTTHKLNCDPSRIYKPQTRLKRKQPVRKRQ |
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| Function | Nuclease that induces DNA fragmentation andchromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. | ||||
| KEGG Pathway | |||||
| Reactome Pathway | |||||