Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT2ZSKV)

• DTT Name: HUMAN eukaryotic translation initiation factor 4E family member 2 (EIF4E2)
• Synonyms: 4EHP; IF4e; 4E-LP; h4EHP; EIF4EL3
• Gene Name: EIF4E2
• BioChemical Class: Eukaryotic initiation factor 4E family
• UniProt ID: Q53RG0_HUMAN
• TTD ID: T01570
• Sequence:
  MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNY
  TFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGI
  KPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDII
  SIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQNLWKP
  RLNVP
• Function: Human protein eukaryotic translation initiation factor 4E family member 2 interacts with SARS-CoV-2 Nsp2? protein with high significance, which indicates EIF4E2 as a potential therapeutic target.
• KEGG Pathway:
  EGFR tyrosine kinase inhibitor resistance (hsa01521)
  HIF-1 signaling pathway (hsa04066)
  mTOR signaling pathway (hsa04150)
  PI3K-Akt signaling pathway (hsa04151)
  Longevity regulating pathway (hsa04211)
  Insulin signaling pathway (hsa04910)

References

• [1] A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.