Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT36N7Z)

• DTT Name: Signal transduction protein Lnk (SH2B3)
• Synonyms: SH2B3; SH2B adapter protein 3; Lymphocyte-specific adapter protein Lnk; Lymphocyte adapter protein
• Gene Name: SH2B3
• DTT Type: Literature-reported target; [1]
• BioChemical Class: SH2B adapter family
• UniProt ID: SH2B3_HUMAN
• TTD ID: T44585
• Sequence:
  MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
  ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
  SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
  KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
  DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
  ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
  CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
  RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
  LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
  HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
• Function: Links T-cell receptor activation signal to phospholipaseC-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
• KEGG Pathway: Neurotrophin signaling pathway (hsa04722)
• Reactome Pathway:
  Negative regulation of FLT3 (R-HSA-9706369)
  Factors involved in megakaryocyte development and platelet production (R-HSA-983231)
  Regulation of KIT signaling (R-HSA-1433559)

References

• [1] Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. J Clin Invest. 2015 Mar 2;125(3):1189-202.