Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT390KA)

DTT Name	Geminin (GMNN)
Synonyms	geminin DNA replication inhibitor; MGORS6
Gene Name	GMNN
DTT Type	Literature-reported target	[1]
UniProt ID	GEMI_HUMAN
TTD ID	T57387
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTS TTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKL HKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEET VEDSLVEDSEIGTCAEGTVSSSTDAKPCI
Function	It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC).
Reactome Pathway	Activation of the pre-replicative complex (R-HSA-68962 ) Switching of origins to a post-replicative state (R-HSA-69052 ) Assembly of the pre-replicative complex (R-HSA-68867 )

References

1	Peptide binding to Geminin and inhibitory for DNA replication. Biochem Biophys Res Commun. 2004 Apr 23;317(1):218-22.