Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT39EZT)

• DTT Name: Nuclear receptor coactivator 4 (NCOA4)
• Synonyms: Ret-activating protein ELE1; RFG; NCoA-4; ELE1; Androgen receptor-associated protein of 70 kDa; Androgen receptor coactivator 70 kDa protein; ARA70 (dARA70N); ARA70; 70 kDa androgen receptor coactivator; 70 kDa AR-activator
• Gene Name: NCOA4
• DTT Type: Literature-reported target; [1]
• UniProt ID: NCOA4_HUMAN
• TTD ID: T45794
• Sequence:
  MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHL
  ECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSV
  CLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLE
  KRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTS
  SRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMD
  LSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEI
  ENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDE
  NCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPS
  RIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWV
  LPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLK
  VDKEKWLYRTPLQM
• Function: Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Enhances the androgen receptor transcriptional activity in prostate cancer cells.
• KEGG Pathway:
  Ferroptosis (hsa04216)
  Pathways in cancer (hsa05200)
  Thyroid cancer (hsa05216)

References

• [1] Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 in prostate cancer cells. J Biol Chem. 2003 May 30;278(22):19619-26.