Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT39YVO)

• DTT Name: Beta-chimaerin (CHN2)
• Synonyms: Rho-GTPase-activating protein 3; CHN2; Beta2-chimaerin; Beta-chimerin
• Gene Name: CHN2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Zinc-finger
• UniProt ID: CHIO_HUMAN
• TTD ID: T52566
• Sequence:
  MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF
  HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF
  ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT
  NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA
  QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE
  IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP
  IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN
  FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF
• Function: Gtpase activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
• Reactome Pathway: RAC1 GTPase cycle (R-HSA-9013149)

References

• [1] Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters. J Biol Chem. 1997 Oct 17;272(42):26488-96.