Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3DQUT)

• DTT Name: Bacterial Lantibiotic mersacidin (Bact glmM)
• Synonyms: glmM of Escherichia coli; Protein mrsA; Mersacidin
• Gene Name: Bact glmM
• DTT Type: Literature-reported target; [1]
• UniProt ID: GLMM_ECOLI
• TTD ID: T64520
• EC Number: EC 5.4.2.10
• Sequence:
  MSNRKYFGTDGIRGRVGDAPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLES
  ALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTK
  LPDAVEEAIEAEMEKEISCVDSAELGKASRIVDAAGRYIEFCKATFPNELSLSELKIVVD
  CANGATYHIAPNVLRELGANVIAIGCEPNGVNINAEVGATDVRALQARVLAEKADLGIAF
  DGDGDRVIMVDHEGNKVDGDQIMYIIAREGLRQGQLRGGAVGTLMSNMGLELALKQLGIP
  FARAKVGDRYVLEKMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLAAMARNHMSLH
  DLCSGMKMFPQILVNVRYTAGSGDPLEHESVKAVTAEVEAALGNRGRVLLRKSGTEPLIR
  VMVEGEDEAQVTEFAHRIADAVKAV
• Function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Can also catalyze the formation of glucose-6-P from glucose-1-P, although at a 1400-fold lower rate.
• KEGG Pathway:
  Amino sugar and nucleotide sugar metabolism (ecj00520)
  Metabolic pathways (ecj01100)
  Biosynthesis of nucleotide sugars (ecj01250)
• BioCyc Pathway:
  MetaCyc:PHOSGLUCOSAMINEMUT-MON
  EcoCyc:PHOSGLUCOSAMINEMUT-MON

Molecular Interaction Atlas (MIA) of This DTT

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,3-Didehydroalanine	DM6SBPI	Discovery agent	N.A.	Investigative	[2]
2-Thioethenamine	DMEY9T2	Discovery agent	N.A.	Investigative	[2]
Alpha-Aminobutyric Acid	DMW1LF0	Discovery agent	N.A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [2] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.