Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT3W4IX)

• DTT Name: NADPH:adrenodoxin oxidoreductase (FDXR)
• Synonyms: NADPH:adrenodoxin oxidoreductase, mitochondrial; FerredoxinNADP(+) reductase; Ferredoxin reductase; FDXR; Adrenodoxin reductase
• Gene Name: FDXR
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Ferredoxin--NADP reductase type 1
• UniProt ID: ADRO_HUMAN
• TTD ID: T04685
• EC Number: EC 1.18.1.6
• Sequence:
  MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKH
  PQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVP
  ELREAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAV
  ILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKE
  LREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASAS
  RAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSI
  GYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQM
  LLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLV
  DPQEMLRLLGH
• Function: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitaminD3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
• Reactome Pathway:
  Endogenous sterols (R-HSA-211976)
  Electron transport from NADPH to Ferredoxin (R-HSA-2395516)
  Defective CYP11A1 causes AICSR (R-HSA-5579026)
  Pregnenolone biosynthesis (R-HSA-196108)
• BioCyc Pathway: MetaCyc:HS08587-MON

References

• [1] Plasma membrane NADH-oxidoreductase system: a critical review of the structural and functional data. Antioxid Redox Signal. 2000 Summer;2(2):197-212.