Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT40HS5)

DTT Name Gastric inhibitory polypeptide (GIP)
Synonyms Glucose-dependent insulinotropic polypeptide; GIP
Gene Name GIP
DTT Type
Literature-reported target
 [1]
BioChemical Class
Glucagon
UniProt ID
GIP_HUMAN
TTD ID
T11453
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISD
YSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPA
KNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR
Function Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
KEGG Pathway
Insulin secretion (hsa04911 )
Reactome Pathway
Glucagon-type ligand receptors (R-HSA-420092 )
G alpha (s) signalling events (R-HSA-418555 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY3493269 DM3Y5QZ Type 2 diabetes 5A11 Phase 1 [2]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Type 2 diabetes 5A11 Liver tissue 2.54E-01 -0.2 -0.76
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References

1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight