Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT43L8U)

DTT Name	Alpha-2-HS-glycoprotein (AHSG)
Synonyms	PRO2743; Ba-alpha-2-glycoprotein; Alpha2-HS glycoprotein
Gene Name	AHSG
DTT Type	Literature-reported target	[1]
BioChemical Class	Fetuin family
UniProt ID	FETUA_HUMAN
TTD ID	T45289
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTL NQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLK LDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNF QLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGG AEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL LAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG RIRHFKV
Function	Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Reactome Pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 ) Neutrophil degranulation (R-HSA-6798695 ) Post-translational protein phosphorylation (R-HSA-8957275 ) Platelet degranulation (R-HSA-114608 )

References

1	The use of biomarkers for assessing HAART-associated renal toxicity in HIV-infected patients. Curr HIV Res. 2012 Sep;10(6):521-31.