Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4EFTR)

DTT Name	Stanniocalcin-2 (STC2)
Synonyms	Stanniocalcin-related protein; STCRP; STC-related protein; STC-2
Gene Name	STC2
DTT Type	Literature-reported target	[1]
UniProt ID	STC2_HUMAN
TTD ID	T58548
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MCAERLGQFMTLALVLATFDPARGTDATNPPEGPQDRSSQQKGRLSLQNTAEIQHCLVNA GDVGCGVFECFENNSCEIRGLHGICMTFLHNAGKFDAQGKSFIKDALKCKAHALRHRFGC ISRKCPAIREMVSQLQRECYLKHDLCAAAQENTRVIVEMIHFKDLLLHEPYVDLVNLLLT CGEEVKEAITHSVQVQCEQNWGSLCSILSFCTSAIQKPPTAPPERQPQVDRTKLSRAHHG EAGHHLPEPSSRETGRGAKGERGSKSHPNAHARGRVGGLGAQGPSGSSEWEDEQSEYSDI RR
Function	Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Reactome Pathway	Post-translational protein phosphorylation (R-HSA-8957275 ) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 )

References

1	Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction. Cardiovasc Diabetol. 2018 Apr 30;17(1):63.