Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4FX9Y)

DTT Name	Succinate receptor (SUCNR1)
Synonyms	Succinate receptor 1; P2Y purinoceptor 1-like; GPR91; G-protein coupled receptor 91
Gene Name	SUCNR1
DTT Type	Literature-reported target	[1]
UniProt ID	SUCR1_HUMAN
TTD ID	T70633
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNI YLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDR YLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGD PNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVI FSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGD HFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
Function	Receptor for succinate.
KEGG Pathway	cAMP signaling pathway (hsa04024 )
Reactome Pathway	G alpha (i) signalling events (R-HSA-418594 ) Class A/1 (Rhodopsin-like receptors) (R-HSA-373076 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID21571530C5g	DMEF8GV	Discovery agent	N.A.	Investigative	[1]
PMID21571530C7e	DMPBITK	Discovery agent	N.A.	Investigative	[1]
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References

1	Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602.