Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4LXBC)

• DTT Name: Hedgehog signaling pathway (HS pathway)
• Gene Name: HS pathway
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T69189

Molecular Interaction Atlas (MIA) of This DTT

2 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[2]
PF-04449913	DMSB068	Chronic myelomonocytic leukaemia	2A40	Approved	[1]

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ENV-101	DMFOI3T	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[3]
Patidegib	DM2NJYC	Basal cell carcinoma	2C32	Phase 2	[4]

References

• [1] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Development of taladegib as a sonic hedgehog signaling pathway inhibitor. Arch Pharm Res. 2017 Dec;40(12):1390-1393.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)