Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4SCBE)

DTT Name Cytomegalovirus IE2 region messenger RNA (CMV IE2 mRNA)
Synonyms Viral transcription factor IE2 (mRNA); UL122 (mRNA); Protein UL122 (mRNA); IE2 (mRNA)
Gene Name CMV IE2 mRNA
DTT Type
Successful target
 [1]
BioChemical Class
mRNA target
UniProt ID
VIE2_HCMVA
TTD ID
T07035
Sequence
MESSAKRKMDPDNPDEGPSSKVPRPETPVTKATTFLQTMLRKEVNSQLSLGDPLFPELAE
ESLKTFEQVTEDCNENPEKDVLAELGDILAQAVNHAGIDSSSTGPTLTTHSCSVSSAPLN
KPTPTSVAVTNTPLPGASATPELSPRKKPRKTTRPFKVIIKPPVPPAPIMLPLIKQEDIK
PEPDFTIQYRNKIIDTAGCIVISDSEEEQGEEVETRGATASSPSTGSGTPRVTSPTHPLS
QMNHPPLPDPLGRPDEDSSSSSSSSCSSASDSESESEEMKCSSGGGASVTSSHHGRGGFG
GAASSSLLSCGHQSSGGASTGPRKKKSKRISELDNEKVRNIMKDKNTPFCTPNVQTRRGR
VKIDEVSRMFRNTNRSLEYKNLPFTIPSMHQVLDEAIKACKTMQVNNKGIQIIYTRNHEV
KSEVDAVRCRLGTMCNLALSTPFLMEHTMPVTHPPEVAQRTADACNEGVKAAWSLKELHT
HQLCPRSSDYRNMIIHAATPVDLLGALNLCLPLMQKFPKQVMVRIFSTNQGGFMLPIYET
AAKAYAVGQFEQPTETPPEDLDTLSLAIEAAIQDLRNKSQ
Function
Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection. In addition, activates quiescent cells to reenter the cell cycle and upregulates several E2F-responsive genes, which are responsible for pushing the cell into S phase. In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomivirsen sodium DMBEP7G Cytomegalovirus retinitis 9B72.00 Approved [1]
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8 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 12659 DMZGKHO Discovery agent N.A. Investigative [2]
ISIS 12660 DMNOPWB Discovery agent N.A. Investigative [2]
ISIS 2918 DMJTHXY Discovery agent N.A. Investigative [3]
ISIS 2919 DMVMF5X Discovery agent N.A. Investigative [3]
ISIS 2920 DMJFLK0 Discovery agent N.A. Investigative [3]
ISIS 2921 DMDZAKS Discovery agent N.A. Investigative [3]
ISIS 3246 DM56EZC Discovery agent N.A. Investigative [3]
ISIS 3300 DM2TIO1 Discovery agent N.A. Investigative [2]
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⏷ Show the Full List of 8 Investigative Drug(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
2 US patent application no. 5,767,102, Antisense composition and method for treatment of CMV infection.
3 US patent application no. 5,442,049, Oligonucleotides for modulating the effects of cytomegalovirus infections.