Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT58ZYW)

• DTT Name: Mycobacterium Isocitrate lyase (MycB icl)
• Synonyms: Isocitratase; Isocitrase; ICL
• Gene Name: MycB icl
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Carbon-carbon lyase
• UniProt ID: ACEA_MYCTU
• TTD ID: T09215
• EC Number: EC 4.1.3.1
• Sequence:
  MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQL
  HDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQV
  VRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSH
  WEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSD
  VDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEA
  VKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFD
  LAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTG
  STEEGQFH
• Function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway.
• KEGG Pathway:
  Glyoxylate and dicarboxylate metabolism (mtu00630)
  Metabolic pathways (mtu01100)
  Biosynthesis of secondary metabolites (mtu01110)
  Microbial metabolism in diverse environments (mtu01120)
  Carbon metabolism (mtu01200)
• BioCyc Pathway: MetaCyc:G185E-4594-MON

Molecular Interaction Atlas (MIA) of This DTT

9 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,2',3-Tribromo-4,4',5,5'-tetrahydroxybibenzyl	DMG7EPF	Discovery agent	N.A.	Investigative	[2]
3-bromopyruvate	DMYL3ST	Discovery agent	N.A.	Investigative	[1]
3-nitropropionate	DMH798G	Discovery agent	N.A.	Investigative	[1]
5,5'-methylenebis(3,4-dibromobenzene-1,2-diol)	DMZ693W	Discovery agent	N.A.	Investigative	[2]
Bis(2,3-dibromo-4,5-dihydroxyphenyl)ether	DMQ7KR1	Discovery agent	N.A.	Investigative	[2]
Bis(3-bromo-4,5-dihydroxyphenyl)methanone	DMUN50H	Discovery agent	N.A.	Investigative	[2]
Glyoxalate, Glyoxylate	DMQUP7O	Discovery agent	N.A.	Investigative	[3]
Halisulfate 1	DMJB87Q	Discovery agent	N.A.	Investigative	[4]
Hydrohalisulfate 1	DM0HQF6	Discovery agent	N.A.	Investigative	[4]

References

• [1] Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000 Aug;7(8):663-8.
• [2] Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6.