Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT5XOKS)

• DTT Name: Leishmania Carbamoyl-phosphate synthase (Leishm CPS)
• Synonyms: Carbamoyl-phosphate synthase, putative
• Gene Name: Leishm CPS
• DTT Type: Discontinued target; [1]
• BioChemical Class: Carbon-nitrogen ligase
• UniProt ID: E9BCR2_LEIDB
• TTD ID: T13609
• Sequence:
  MEHYAKAELVLHGGERFEGYSFGYEESVAGEVVFATGMVGYPESLSDPSYHGQILVLTSP
  MVGNYGVPRVEEDLFGVTKYFESTDGQIHVSAVVVQEYCDQPDHWEMYETLGTWLRKNKV
  PGMMMVDTRSIVLKLRDMGTALGKVLVAGNDVPFMDPNTRNLVAEVSTKTRVTHGHGTLR
  ILVIDMGVKLNTLRCLLKHDVTLIVVPHDWDITTEVYDGLFITNGPGNPQICTSTIRSVR
  WALQQDKPIFGICMGNQMLCLAAGGTTYKMKYGHRGQNQPCKCNIDGRVVITTQNHGFAV
  DFKTLPSGEWEEYFTNSNDGSNEGLWHKTKPFCSVQFHPEGRCGPQDTEYLFSEYVCRVK
  ESKVREVAKFKPRKVLVLGAGGIVIAQAGEFDYSGSQCLKSLREEGMETVLINPNIATVQ
  TDDEMADHIYFVPLTVEAVERVIEKERPDGILLGWGGQTALNCGVKLDELGVLKKYNVQV
  LGTPVSVIAVTEDRELFRDTLLQINEQVAKSAAVMSVEEAVAASKDIGFPMMVRAAYCLG
  GQGSGIVENMEELRHKVEVALAASPQVLLEESVAGWKEIEYEVVRDIYDNCITVCNMENF
  DPMGVHTGESIVVAPSQTLSNDEFHMLRSASIKIIRHLGIVGECNIQYGLDPFSHRYVVI
  EVNARLSRSSALASKATGYPLAHVATKIALGKGLFEITNGVTKTTMACFEPSMDYIAVKM
  PRWDLHKFNMVSEEIGSMMKSVGEVMSIGRTFEEALQKAIRMVDPSYTGFSLPDRFAGVD
  FDYMEHIRHPTPYRLFALCRALLDGHSAEELYQMTKITRFFLYKLEKLVRLSKATSTLYA
  NKLTEMPRENLLNMKAHGFSDRQLAQLLNSTAADVRARRVELNVMPLIKQIDTVAGEYPA
  AQCCYLYSTYNAQRDDVPFTERMYAVLGCGVYRIGNSVEFDYGGVLVARELRRLGNKVIL
  INYNPETVSTDYDECDRLYFDEVSEETVLDILTKERVRGVVISLGGQIVQNMALSLKKSG
  LPILGTDPANIDMAEDRNKFSKMCDELGVPQPEWISATSVEQVHEFCDTVGYPALVRPSY
  VLSGSAMAVIANKEDVTRYLKEASFVSGEHPVVVSKYYEAATEYDVDIVAHHGRVLCYAI
  CEHVENAGVHSGDATMFLPPQNTDKDTMKRIYDSVNRIAEKLDVVGPMNVQFLLTAEGQL
  RVIEANVRSSRSVPFVSKTLGISFPSVMVSAFLARKDQNLVPIKRAKMTHIGCKASMFSF
  NRLAGADPILGVEMASTGEIGVFGRDKHEVFLKAMLCQNFKIPQKGVFFSSDVDSQTEAL
  CPYIQHLVRRGLKVYGTTKTAAVLHEYGIQCEVLLQRGELPSGDASESNRLAVYDEEVAK
  KEKFDLVIQLRDKRRDFVLRRCTRETAPPDYWVRRLAVDYNIPLLTEPSIVKMFCECMDL
  PASSIEIEPFRHYVPKIYHKVENNNCAMLRCHKVGLMITNNNDSKVLALRLSQEGLNITC
  FHAYLGGSDIDHFEQAFQSLNVPVEVVDLRSEIANSAFDLIMCQSADERHNWHLSKLSWY
  IFGKYLIPVMRQRRMSVVAQTSKQNKKEAGFEKYVQSNCPEMGVYNAWRDARLMEDFETV
  ADQISFLRKHGIKATVKSNVQVHSSVCGSTYYGDDMRSLPAPSLVKPVRECSVTPEFVSL
  TFRGARCVNINGIDVTPLLALQMANEIAGRNGVGITRTREGAMYETPGMNLLSVGLQFLY
  DVSFDRCAADLFRIYSRHVSQNIGAGQLSEKHTQSAIEAVRFLTSDVSGVVELELHQGEI
  IFLKLSHVQNPVDRRVAPQLVTEEELEEVFQPGNGSFSDVQW
• Function: Catalyses the formation of carbamoyl phosphate from L-glutamine, bicarbonate, and 2 moles of MgATP.
• KEGG Pathway:
  Pyrimidine metabolism (ldo00240)
  Alanine, aspartate and glutamate metabolism (ldo00250)
  Metabolic pathways (ldo01100)
  Biosynthesis of cofactors (ldo01240)

Molecular Interaction Atlas (MIA) of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acivicin	DMPQZ80	N. A.	N. A.	Discontinued in Phase 3	[1]

References

• [1] Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis. Biochem Biophys Res Commun. 1990 Jul 31;170(2):426-32.