Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT63WSF)

• DTT Name: Tumor necrosis factor receptor type II (TNF-R2)
• Synonyms: p80 TNF-alpha receptor; p75; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNFR2; TNFR-II; TNFBR; TNF-RII; TNF-R2; Etanercept; CD120b
• Gene Name: TNFRSF1B
• DTT Type: Literature-reported target; [1]
• UniProt ID: TNR1B_HUMAN
• TTD ID: T53033
• Sequence:
  MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPG
  QHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTC
  RPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICR
  PHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTS
  FLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKV
  PHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGE
  ARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQ
  VPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
• Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
• KEGG Pathway:
  Cytokine-cytokine receptor interaction (hsa04060)
  Viral protein interaction with cytokine and cytokine receptor (hsa04061)
  TNF signaling pathway (hsa04668)
  Adipocytokine signaling pathway (hsa04920)
  Amyotrophic lateral sclerosis (hsa05014)
  Pathways of neurodegeneration - multiple diseases (hsa05022)
  Human immunodeficiency virus 1 infection (hsa05170)
• Reactome Pathway:
  TNFs bind their physiological receptors (R-HSA-5669034)
  Interleukin-10 signaling (R-HSA-6783783)
  Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807)
  Neutrophil degranulation (R-HSA-6798695)
  TNFR2 non-canonical NF-kB pathway (R-HSA-5668541)

References

• [1] The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells. Front Immunol. 2018 Mar 22;9:583.