Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT64EPS)

• DTT Name: Fungal Scytalone dehydratase (Fung SDH1)
• Synonyms: SDH1
• Gene Name: Fung SDH1
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Alpha-carbonic anhydrase
• UniProt ID: SCYD_MAGO7
• TTD ID: T86829
• EC Number: EC 4.2.1.94
• Sequence:
  MGSQVQKSDEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLWEA
  MPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRVPHQRYKDTTMKE
  VTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDFDRIFEDGRETFGDK
• Function: Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.

Molecular Interaction Atlas (MIA) of This DTT

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(3-Phenyl-propyl)-quinazolin-4-yl-amine	DM1C90Y	Discovery agent	N.A.	Investigative	[2]
2-Hydroxy-N-(3-phenyl-propyl)-benzamide	DMWSR13	Discovery agent	N.A.	Investigative	[2]
5-Fluoro-2-hydroxy-N-isopropyl-benzamide	DMOI7ME	Discovery agent	N.A.	Investigative	[3]
Carpropamid	DMBKQ03	Discovery agent	N.A.	Investigative	[1]
Isoquinolin-1-yl-(3-phenyl-propyl)-amine	DMDF26N	Discovery agent	N.A.	Investigative	[2]

References

• [1] Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus. Biosci Biotechnol Biochem.2004 Mar;68(3):615-21.
• [2] A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydratase, Bioorg. Med. Chem. Lett. 3(8):1605-1608 (1993).
• [3] Binding dynamics of two water molecules constrained within the scytalone dehydratase binding pocket. Bioorg Med Chem Lett. 2000 Jan 3;10(1):23-6.