Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6ERZB)

DTT Name Bacterial Phosphatidylcholine-specificphospholipase C (Bact plcN)
Synonyms plcN; Phosphatidylcholine-hydrolyzing phospholipase C; Phosphatidylcholine cholinephosphohydrolase; PLC-N; PC-PLC; Non-hemolytic phospholipase C; Lecithinase
Gene Name Bact plcN
DTT Type
Literature-reported target
 [1]
BioChemical Class
Phosphoric diester hydrolase
UniProt ID
PHLN_BURPS
TTD ID
T93511
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTNQNRRDFLRLAAGTAGAAALQLFPPVIREALAIPANRRTGTIRDVEHIVILMQENRSF
DHYFGKLRGVRGFGDPRPLALQNGKSVFHQPVLLGPAELLPFHPDASNLGMQFLQDLPHG
WQDMHGAWNKGRYDRWIANKGTTTMAYLERDDIPFHYQLADAFTICDAYHCSIPSSTDPN
RYYMWTGYVGNDGAGGGPVLGNEEAGYGWSTYPETLEQAGVSWKIYQDIGTGLDAAGSWG
WTQNPYIGNYGDNSLLYFNQYRNAQPGSPLYDKARTGTNVSAGGTLFDVLQQDVKNGTLP
QVSWICAPEAYSEHPNWPANYGAWYVEQVLKALTSNPDVWSKTALFITYDENDGFFDHVA
PPFAPQSRENGLSTVSTAGEIFAGDATHMAGPYGLGPRVPMLVVSPWTKGGWVCSQTFDH
TSLLQFIEARFNDRYSVRAPNVTPWRRAVCGDLTSAFNFSSPDGSWPQLPDTSGYAPPDR
NRHPSYVPVPPAAQSMPKQEAGLRAARALPYELFVLGRIDQSTGKFKLTFANTGRAGAAF
QVTAGNRLDGPWAYTVEARKRLSDEWSTALTLSIYDLTVYGPNGFLCQFRGSTAAALGLS
ANPEVIYGYDVANGNITLRLSNRGRAAVRLTVTNAYGNAAPRVYELKPGQRINDYWDLRD
SHSWYDLSVSDGAPNGFLRRFAGHVETGRPSTSDPLIATA
Function Hydrolyzes phosphatidylserine as well as phosphatidylcholine.
KEGG Pathway
Inositol phosphate metabolism (bps00562 )
Glycerophospholipid metabolism (bps00564 )
Metabolic pathways (bps01100 )
Biosynthesis of secondary metabolites (bps01110 )
Quorum sensing (bps02024 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
D609 DM0M81E Discovery agent N.A. Investigative [1]
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References

1 Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. J Exp Med. 1996 Aug 1;184(2):725-33.