Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6GSR3)

DTT Name Interleukin-1 receptor antagonist protein (IL1RN)
Synonyms IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 inhibitor; Anakinra
Gene Name IL1RN
DTT Type
Clinical trial target
 [1]
UniProt ID
IL1RA_HUMAN
TTD ID
T63174
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYL
QGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQD
KRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
Function
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. {ECO:0000250|UniProtKB:P25085, ECO:0000269|PubMed:7775431}.
KEGG Pathway
3557 (hsa )
Reactome Pathway
( )
(R-HSA-6783783 )
(R-HSA-9020702 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
GNSC-001 DMH3TV7 Osteoarthritis FA00-FA05 Phase 1 [2]
Humantakinogene hadenovec DMOQOKZ Osteoarthritis FA00-FA05 Phase 1 [1]
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References

1 ClinicalTrials.gov (NCT04119687) An Open-Label, Single Ascending Dose Study to Assess the Safety and Tolerability of FX201 in Patients With Osteoarthritis of the Knee. U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Genascence