Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6HPVC)

DTT Name Guanylate cyclase (GC)
Synonyms Guanylyl Cyclase
Gene Name GC
DTT Type
Successful target
 [1]
BioChemical Class
Phosphorus-oxygen lyase
UniProt ID
NOUNIPROTAC
TTD ID
T71398

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
5 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythrityl Tetranitrate DMFGQ2S Angina pectoris BA40 Approved [1]
Isosorbide Dinitrate DMBI4JG Anal fissure DB50.0 Approved [1]
Isosorbide Mononitrate DMYLMU0 Angina pectoris BA40 Approved [1]
Methylene blue DMJAPE7 Acquired methemoglobinemia 3A93 Approved [2]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1]
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2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
IW-1701 DM457XO Sickle-cell disorder 3A51 Phase 2 [3]
Pirsidomine DMHI6GE Angina pectoris BA40 Phase 2 [4]
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References

1 Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201.
2 Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82.
3 Clinical pipeline report, company report or official report of Cyclerion Therapeutics.
4 Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12.