Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6LDTK)

DTT Name Bacterial Glutamate-1-semialdehyde aminomutase (Bact hemL)
Synonyms Glutamate-1-semialdehyde aminotransferase; Glutamate-1-semialdehyde 2,1-aminomutase; GSA-AT; GSA
Gene Name Bact hemL
DTT Type
Literature-reported target
 [1]
BioChemical Class
Intramolecular transferases
UniProt ID
GSA_ECOLI
TTD ID
T87542
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWG
PMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAQLVTELVPTMDMVRMVNSGTEATM
SAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKYTLTCT
YNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVM
TGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSG
NPIAMAAGFACLNEVAQPGVHETLDELTTRLAEGLLEAAEEAGIPLVVNHVGGMFGIFFT
DAESVTCYQDVMACDVERFKRFFHMMLDEGVYLAPSAFEAGFMSVAHSMEDINNTIDAAR
RVFAKL
Function Catalyses the formation of this key precursor of tetrapyrroles.
KEGG Pathway
Porphyrin metabolism (ecj00860 )
Metabolic pathways (ecj01100 )
Biosynthesis of secondary metabolites (ecj01110 )
Microbial metabolism in diverse environments (ecj01120 )
Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway
MetaCyc:GSAAMINOTRANS-MON
EcoCyc:GSAAMINOTRANS-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diaminopropyl sulfate DMDGIT6 Discovery agent N.A. Investigative [1]
Gabaculine DMH17MU Discovery agent N.A. Investigative [2]
------------------------------------------------------------------------------------

References

1 Reactions of glutamate 1-semialdehyde aminomutase with R- and S-enantiomers of a novel, mechanism-based inhibitor, 2,3-diaminopropyl sulfate. Biochemistry. 2000 Mar 21;39(11):3091-6.
2 A suicide vector for allelic recombination involving the gene for glutamate 1-semialdehyde aminotransferase in the cyanobacterium Synechococcus PCC 7942. Mol Gen Genet. 1997 Jul;255(4):392-9.