Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6TMZU)

DTT Name Mycobacterium Biosynthetic alanine racemase (MycB alr)
Synonyms D-alanine racemase; Alr; Alanine racemase; AlaR
Gene Name MycB alr
DTT Type
Successful target
 [1]
BioChemical Class
Racemases and epimerases
UniProt ID
ALR_MYCSM
TTD ID
T14582
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 5.1.1.1
Sequence
MQTTEPMTPPAPLASAQTVIDLGAIDHNVRVLRELAGSADVMAVVKADAYGHGALPVART
ALAAGAAALGVATIPEALALREGGITAPVLAWLHPPGTDFAPAIAADVEVAVSSRRQLEQ
VTAAAAEVGRTATVTVKVDTGLSRNGVGAADYPEVLDVLRRAQADGAIRVRGLMSHLVHG
DDPENPFNGLQGQRLADMRVYAREHGVDYEVAHLCNSPAAMTRPDLAFEMVRPGISLYGL
SPIPERGDMGLRPAMTLKCPVALVRSVHAGDGVSYGHRWVADRDTTLGLLPIGYADGVYR
ALSGRIDVLIKGRRRRAVGRICMDQFVVDLGPDADDVAVGDDAILFGPGANGEPTAQDWA
ELLDTIHYEVVTSPRGRVTRTYLPAGQQD
Function Catalyzes the interconversion of L-alanine and D- alanine. Overexpression due to a natural mutation in the promoter is responsible for mediating resistance to D-cycloserine (DCS) in mycobacteria.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cycloserine DMT1I52 Bacterial infection 1A00-1C4Z Approved [1]
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9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
3-fluorovinylglycine DMECBLA Discovery agent N.A. Investigative [2]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [1]
Lysine Nz-Carboxylic Acid DMW1YK3 Discovery agent N.A. Investigative [1]
N-(5'-Phosphopyridoxyl)-D-Alanine DM3FCAI Discovery agent N.A. Investigative [1]
Propanoic Acid DM9TN2W Discovery agent N.A. Investigative [1]
Propionate DM0O8N6 Discovery agent N.A. Investigative [3]
Pyridoxamine-5'-Phosphate DMQ6POC Discovery agent N.A. Investigative [1]
Pyridoxyl-Alanine-5-Phosphate DMUVCWY Discovery agent N.A. Investigative [1]
Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate DM7AW0X Discovery agent N.A. Investigative [1]
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⏷ Show the Full List of 9 Investigative Drug(s)

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Mechanism-based inactivation of alanine racemase by 3-halovinylglycines. J Biol Chem. 1991 Nov 15;266(32):21657-65.
3 Molecular dynamics studies of alanine racemase: a structural model for drug design. Biopolymers. 2003 Oct;70(2):186-200.