Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT6Y1PG)

DTT Name	Solute carrier family 40 member 1 (SLC40A1)
Synonyms	SLC11A3; MSTP079; IREG1; Ferroportin-1; FPN1
Gene Name	SLC40A1
DTT Type	Clinical trial target	[1]
BioChemical Class	Ferroportin protein
UniProt ID	S40A1_HUMAN
TTD ID	T86264
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLL TAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHEL LTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRI DQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLK EEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWV SYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAF TWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITP TKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLL QENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFR FAQNTLGNKLFACGPDAKEVRKENQANTSVV
Function	Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation.
KEGG Pathway	Mineral absorption (hsa04978 )
Reactome Pathway	Iron uptake and transport (R-HSA-917937 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY2928057	DMRDEKZ	Anaemia	3A90	Phase 2	[2]
Ferroportin mab	DM13YK0	Anemia	3A00-3A9Z	Phase 1	[1]
M012	DME6UNO	Myelodysplastic syndrome	2A37	Phase 1	[3]
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Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA)

Jump to Detail Molecular Expression Atlas of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Shwachman-Diamond syndrome	3B64	Bone marrow	6.38E-02	0.15	0.5
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The Drug Transporter (DTP) Role of This DTT

DTT DTP Name

Iron-regulated transporter 1 (SLC40A1) DTP Info

Gene Name

SLC40A1

1 Approved Drug(s) Transported by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zinc salts	DMZ4R3Q	Arthritis	FA20	Approved	[4]
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References

1	The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161.
2	Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation. Am J Hematol. 2012 April; 87(4): 392-400.
3	Hepcidin agonists as therapeutic tools. Blood. 2018 Apr 19;131(16):1790-1794.
4	Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012 Sep;1823(9):1426-33.