Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT72OKI)

DTT Name P2Y purinoceptor 14 (P2RY14)
Synonyms UDP-glucose receptor; P2Y14; KIAA0001; GPR105; G-protein coupled receptor 105
Gene Name P2RY14
DTT Type
Literature-reported target
 [1]
UniProt ID
P2Y14_HUMAN
TTD ID
T16555
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYL
KNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRY
YKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELG
RKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVF
VFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQ
PFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
Function Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.
KEGG Pathway
Neuroactive ligand-receptor interaction (hsa04080 )
Reactome Pathway
G alpha (i) signalling events (R-HSA-418594 )
P2Y receptors (R-HSA-417957 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
8 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-thio-UDP DM84R6C Discovery agent N.A. Investigative [2]
alpha.beta-methylene-2-thio-UDP DMLGMTQ Discovery agent N.A. Investigative [2]
MRS2690 DMNS3RT Discovery agent N.A. Investigative [1]
MRS2802 DMWKZCY Discovery agent N.A. Investigative [2]
MRS2905 DMGCPHO Discovery agent N.A. Investigative [3]
PPTN DML72JT Discovery agent N.A. Investigative [4]
UDP-glucose DMLT4JA Discovery agent N.A. Investigative [5]
UDP-glucuronic acid DMW16X2 Discovery agent N.A. Investigative [6]
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⏷ Show the Full List of 8 Investigative Drug(s)

References

1 The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013 Mar;9(1):31-40.
2 Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80.
3 Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24.
4 A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9.
5 Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics. 2001 Dec;78(3):124-8.
6 Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8.