Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7EASG)

• DTT Name: Plasmodium Cysteine protease falcipain-2 (Malaria CPF2)
• Synonyms: Falcipain 2; Cysteine proteinase falcipain 2a
• Gene Name: Malaria CPF2
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Protease
• UniProt ID: Q9N6S8_PLAFA
• TTD ID: T44614
• EC Number: EC 3.4.22.-
• Sequence:
  MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
  KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
  NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
  EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
  LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
  RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
  RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
  LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
  PLIE
• Function: A papain family cysteine protease and important hemoglobinase of erythrocytic Plasmodium falciparum parasites.
• BioCyc Pathway: MetaCyc:MON-15378

Molecular Interaction Atlas (MIA) of This DTT

1 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pepstatin	DM9S1EA	Malaria	1F40-1F45	Terminated	[1]

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FITC-LMNNAEHINQFYMFI	DMW2VOX	Discovery agent	N.A.	Investigative	[2]
Leupeptin	DMU075F	Malaria	1F40-1F45	Investigative	[1]
Vinylsulphones	DMNFVO7	Infection of P. falciparum	1F40	Investigative	[3]

References

• [1] Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
• [2] A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development. J Med Chem. 2008 Jun 12;51(11):3116-23.
• [3] Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.