General Information of Drug Therapeutic Target (DTT) (ID: TT7EV4P)

DTT Name Glucose-6-phosphatase 2 (G6PC2)
Synonyms IGRP; G6PC2
Gene Name G6PC2
DTT Type
Literature-reported target
[1]
BioChemical Class
Phosphoric monoester hydrolase
UniProt ID
G6PC2_HUMAN
TTD ID
T79726
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 3.1.3.9
Sequence
MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV
AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS
CVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVI
LGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAK
KWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTS
LTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ
Function May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis.
KEGG Pathway
Glycolysis / Gluconeogenesis (hsa00010 )
Galactose metabolism (hsa00052 )
Starch and sucrose metabolism (hsa00500 )
Metabolic pathways (hsa01100 )
FoxO signaling pathway (hsa04068 )
PI3K-Akt signaling pathway (hsa04151 )
AMPK signaling pathway (hsa04152 )
Insulin signaling pathway (hsa04910 )
Adipocytokine signaling pathway (hsa04920 )
Glucagon signaling pathway (hsa04922 )
Insulin resistance (hsa04931 )
Carbohydrate digestion and absorption (hsa04973 )
Reactome Pathway
Gluconeogenesis (R-HSA-70263 )
BioCyc Pathway
MetaCyc:HS14422-MON

References

1 Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8384-8.