Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7JUKC)

DTT Name	Bcl-2-binding component 3 (BBC3)
Synonyms	p53 upregulated modulator of apoptosis; p53 up-regulated modulator of apoptosis; PUMA; JFY1; JFY-1; Bcl2binding component 3
Gene Name	BBC3
DTT Type	Literature-reported target	[1]
BioChemical Class	B-cell lymphoma Bcl-2
UniProt ID	BBC3_HUMAN
TTD ID	T21460
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLC APTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPT QAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLP LPRGHRAPEMEPN
Function	Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis.
KEGG Pathway	Platinum drug resistance (hsa01524 ) p53 signaling pathway (hsa04115 ) Apoptosis (hsa04210 ) Apoptosis - multiple species (hsa04215 ) Hippo signaling pathway (hsa04390 ) Huntington disease (hsa05016 ) Measles (hsa05162 ) Pathways in cancer (hsa05200 ) Colorectal cancer (hsa05210 )
Reactome Pathway	Activation of PUMA and translocation to mitochondria (R-HSA-139915 ) TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (R-HSA-6803204 ) FOXO-mediated transcription of cell death genes (R-HSA-9614657 ) BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (R-HSA-111453 )

References

1	The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) ... Cancer Res. 2007 Jul 1;67(13):6270-7.