Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7KNZQ)

• DTT Name: Thymidine kinase 2 (Mt-TK2)
• Synonyms: dnk; Multispecific deoxynucleoside kinase; Dm-Dnk; Deoxyribonucleoside kinase
• Gene Name: dnk
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Kinase
• UniProt ID: KITM_HUMAN
• TTD ID: T22976
• EC Number: EC 2.7.1.21
• Sequence:
  MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
  SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
  HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
  YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
  MERMLELFEQNRDRILTPENRKHCP
• Function: Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, deoxyadenosine, deoxycytidine and deoxyguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.
• KEGG Pathway:
  Pyrimidine metabolism (hsa00240)
  Drug metabolism - other enzymes (hsa00983)
  Metabolic pathways (hsa01100)
  Nucleotide metabolism (hsa01232)
• Reactome Pathway: Pyrimidine salvage (R-HSA-73614)
• BioCyc Pathway: MetaCyc:HS09420-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MT-1621	DMUNBMA	Thymidine kinase 2 deficiency	5C55.1	Phase 3	[2]

3 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine	DMU3VWA	Discovery agent	N.A.	Investigative	[1]
1-[5-(triphenylmethoxy)pentyl]thymine	DMFHBJM	Discovery agent	N.A.	Investigative	[1]
1-[6-(triphenylmethoxy)hexyl]thymine	DM5NVHO	Discovery agent	N.A.	Investigative	[1]

References

• [1] N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73.
• [2] Clinical pipeline report, company report or official report of Modis Therapeutics.