Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7Q9WR)

• DTT Name: Suppressor of G2 allele of SKP1 homolog (Sgt1)
• Synonyms: Protein SGT1 homolog; Protein 40-6-3
• Gene Name: SUGT1
• DTT Type: Literature-reported target; [1]
• UniProt ID: SGT1_HUMAN
• TTD ID: T75644
• Sequence:
  MAAAAAGTATSQRFFQSFSDALIDEDPQAALEELTKALEQKPDDAQYYCQRAYCHILLGN
  YCVAVADAKKSLELNPNNSTAMLRKGICEYHEKNYAAALETFTEGQKLDIETGFHRVGQA
  GLQLLTSSDPPALDSQSAGITGADANFSVWIKRCQEAQNGSESEVWTHQSKIKYDWYQTE
  SQVVITLMIKNVQKNDVNVEFSEKELSALVKLPSGEDYNLKLELLHPIIPEQSTFKVLST
  KIEIKLKKPEAVRWEKLEGQGDVPTPKQFVADVKNLYPSSSPYTRNWDKLVGEIKEEEKN
  EKLEGDAALNRLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDM
  EWKKY
• Function: May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
• KEGG Pathway: NOD-like receptor signaling pathway (hsa04621)
• Reactome Pathway:
  Purinergic signaling in leishmaniasis infection (R-HSA-9660826)
  The NLRP3 inflammasome (R-HSA-844456)

References

• [1] Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. Int J Oncol. 2010 Mar;36(3):569-75.