Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT87RWS)

DTT Name	Interleukin-19 (IL19)
Synonyms	ZMDA1; NG.1; Melanoma differentiation-associated protein-like protein; IL-19
Gene Name	IL19
DTT Type	Literature-reported target	[1]
BioChemical Class	Cytokine: interleukin
UniProt ID	IL19_HUMAN
TTD ID	T44584
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKLQCVSLWLLGTILILCSVDNHGLRRCLISTDMHHIEESFQEIKRAIQAKDTFPNVTIL STLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQ CQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
Function	Up-regulates IL-6 and TNF-alpha and induces apoptosis. May play some important roles in inflammatory responses.
KEGG Pathway	Cytokine-cytokine receptor interaction (hsa04060 ) Viral protein interaction with cytokine and cytokine receptor (hsa04061 ) JAK-STAT signaling pathway (hsa04630 )
Reactome Pathway	Interleukin-20 family signaling (R-HSA-8854691 )

References

1	Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis. Naunyn Schmiedebergs Arch Pharmacol. 2017 Mar;390(3):261-268.