Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8HWCD)

DTT Name	Staphylococcus DHNA-CoA synthase (Stap-coc menB)
Synonyms	DHNA-CoA synthase; 1,4-dihydroxy-2-naphthoyl-CoA synthase
Gene Name	Stap-coc menB
DTT Type	Literature-reported target	[1]
BioChemical Class	Carbon-carbon lyase
UniProt ID	MENB_STAAC
TTD ID	T57750
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MTNRQWETLREYDEIKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSV IVLTGEGDLAFCSGGDQKKRGHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVG GGNVLNVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNA QEALDMGLVNTVVPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGD ATLLYYTTDEAKEGRDAFKEKRDPDFDQFPKFP
Function	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
KEGG Pathway	Ubiquinone and other terpenoid-quinone biosynthesis (sac00130 ) Metabolic pathways (sac01100 ) Biosynthesis of secondary metabolites (sac01110 ) Biosynthesis of cofactors (sac01240 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetoacetyl-Coenzyme A	DM3HYU8	Discovery agent	N.A.	Investigative	[1]
Coenzyme A	DM1I8LU	Discovery agent	N.A.	Investigative	[1]
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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.