Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8RHGB)

• DTT Name: Bacterial Pyruvate decarboxylase (Bact aceE)
• Synonyms: aceE; Pyruvate decarboxylase E1 component
• Gene Name: Bact aceE
• DTT Type: Successful target; [1]
• BioChemical Class: Aldehyde/oxo donor oxidoreductase
• UniProt ID: ODP1_ECOLI
• TTD ID: T71690
• Sequence:
  MSERFPNDVDPIETRDWLQAIESVIREEGVERAQYLIDQLLAEARKGGVNVAAGTGISNY
  INTIPVEEQPEYPGNLELERRIRSAIRWNAIMTVLRASKKDLELGGHMASFQSSATIYDV
  CFNHFFRARNEQDGGDLVYFQGHISPGVYARAFLEGRLTQEQLDNFRQEVHGNGLSSYPH
  PKLMPEFWQFPTVSMGLGPIGAIYQAKFLKYLEHRGLKDTSKQTVYAFLGDGEMDEPESK
  GAITIATREKLDNLVFVINCNLQRLDGPVTGNGKIINELEGIFEGAGWNVIKVMWGSRWD
  ELLRKDTSGKLIQLMNETVDGDYQTFKSKDGAYVREHFFGKYPETAALVADWTDEQIWAL
  NRGGHDPKKIYAAFKKAQETKGKATVILAHTIKGYGMGDAAEGKNIAHQVKKMNMDGVRH
  IRDRFNVPVSDADIEKLPYITFPEGSEEHTYLHAQRQKLHGYLPSRQPNFTEKLELPSLQ
  DFGALLEEQSKEISTTIAFVRALNVMLKNKSIKDRLVPIIADEARTFGMEGLFRQIGIYS
  PNGQQYTPQDREQVAYYKEDEKGQILQEGINELGAGCSWLAAATSYSTNNLPMIPFYIYY
  SMFGFQRIGDLCWAAGDQQARGFLIGGTSGRTTLNGEGLQHEDGHSHIQSLTIPNCISYD
  PAYAYEVAVIMHDGLERMYGEKQENVYYYITTLNENYHMPAMPEGAEEGIRKGIYKLETI
  EGSKGKVQLLGSGSILRHVREAAEILAKDYGVGSDVYSVTSFTELARDGQDCERWNMLHP
  LETPRVPYIAQVMNDAPAVASTDYMKLFAEQVRTYVPADDYRVLGTDGFGRSDSRENLRH
  HFEVDASYVVVAALGELAKRGEIDKKVVADAIAKFNIDADKVNPRLA
• Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa and co(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) and lipoamide dehydrogenase.
• KEGG Pathway:
  Glycolysis / Gluconeogenesis (ecj00010)
  Citrate cycle (TCA cycle) (ecj00020)
  Pyruvate metabolism (ecj00620)
  Metabolic pathways (ecj01100)
  Biosynthesis of secondary metabolites (ecj01110)
  Microbial metabolism in diverse environments (ecj01120)
  Carbon metabolism (ecj01200)
• BioCyc Pathway:
  MetaCyc:E1P-MON
  EcoCyc:E1P-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin B1	DMZ1WXJ	Vitamin B1 deficiency	5B5A	Approved	[1]

References

• [1] Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.