Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8Z1FE)

DTT Name	Human immunodeficiency virus Tat-TAR RNA interaction (HIV Tat-TAR PPI)
Synonyms	HIV Protein Tat-TAR RNA interaction
Gene Name	HIV Tat-TAR PPI
DTT Type	Literature-reported target	[1]
UniProt ID	TAT_HV1H2-TAR RNA
TTD ID	T56636
Sequence	MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAHQ NSQTHQASLSKQPTSQPRGDPTGPKE
Function	Inhibit Tat-dependent transcription of HIV DNA.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2'-O-Methyl G-Clamp Containing Oligonucleotides	DMO6JRW	Discovery agent	N.A.	Investigative	[1]
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References

1	The synthesis of 2'-O-methyl G-clamp containing oligonucleotides and their inhibition of the HIV-1 Tat-TAR interaction. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1259-62.