Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT958S6)

• DTT Name: Ras-related protein Rab-9A (RAB9A)
• Synonyms: RAB9A
• Gene Name: RAB9A
• DTT Type: Successful target; [1]
• BioChemical Class: Small GTPase superfamily
• UniProt ID: RAB9A_HUMAN
• TTD ID: T66350
• Sequence:
  MAGKSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFVTMQI
  WDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFV
  ILGNKIDISERQVSTEEAQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVLATEDRSD
  HLIQTDTVNLHRKPKPSSSCC
• Function: Involved in the transport of proteins between the endosomes and the trans Golgi network.
• KEGG Pathway: Measles (hsa05162)
• Reactome Pathway:
  RAB geranylgeranylation (R-HSA-8873719)
  RAB GEFs exchange GTP for GDP on RABs (R-HSA-8876198)
  RHOBTB3 ATPase cycle (R-HSA-9706019)
  Retrograde transport at the Trans-Golgi-Network (R-HSA-6811440)

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[1]

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanosine-5'-Diphosphate	DM0MUKQ	Discovery agent	N.A.	Investigative	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.