| DTT Name |
TGFA messenger RNA (TGFA mRNA)
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| Synonyms |
TGF-alpha (40-89) (mRNA); TGF type 1 (40-89) (mRNA); Protransforming growth factor alpha (40-89) (mRNA); ETGF (40-89) (mRNA); EGF-like TGF (40-89) (mRNA) |
| Gene Name |
TGFA
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| DTT Type |
Literature-reported target
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[1] |
| BioChemical Class |
mRNA target
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| UniProt ID |
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| TTD ID |
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| 3D Structure |
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| Sequence |
MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC
RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL
IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
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| Function |
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
| KEGG Pathway |
- EGFR tyrosine kinase inhibitor resistance (hsa01521 )
- MAPK signaling pathway (hsa04010 )
- ErbB signaling pathway (hsa04012 )
- Ras signaling pathway (hsa04014 )
- PI3K-Akt signaling pathway (hsa04151 )
- Estrogen signaling pathway (hsa04915 )
- Pathways in cancer (hsa05200 )
- Colorectal cancer (hsa05210 )
- Renal cell carcinoma (hsa05211 )
- Pancreatic cancer (hsa05212 )
- Glioma (hsa05214 )
- Prostate cancer (hsa05215 )
- Non-small cell lung cancer (hsa05223 )
- Hepatocellular carcinoma (hsa05225 )
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| Reactome Pathway |
- Signaling by EGFR (R-HSA-177929 )
- GRB2 events in EGFR signaling (R-HSA-179812 )
- GAB1 signalosome (R-HSA-180292 )
- SHC1 events in EGFR signaling (R-HSA-180336 )
- EGFR downregulation (R-HSA-182971 )
- COPII-mediated vesicle transport (R-HSA-204005 )
- EGFR interacts with phospholipase C-gamma (R-HSA-212718 )
- Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530 )
- Inhibition of Signaling by Overexpressed EGFR (R-HSA-5638303 )
- RAF/MAP kinase cascade (R-HSA-5673001 )
- Cargo concentration in the ER (R-HSA-5694530 )
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (R-HSA-6811558 )
- Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825 )
- Clathrin-mediated endocytosis (R-HSA-8856828 )
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (R-HSA-8866910 )
- Extra-nuclear estrogen signaling (R-HSA-9009391 )
- Estrogen-dependent gene expression (R-HSA-9018519 )
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling (R-HSA-9634638 )
- PIP3 activates AKT signaling (R-HSA-1257604 )
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