Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9BPT3)

DTT Name	Orexin receptor (HCRTR)
Synonyms	Hypocretin receptor
Gene Name	HCRTR
DTT Type	Patented-recorded target	[1]
UniProt ID	NOUNIPROTAC
TTD ID	T86671
Function	Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daridorexant	DMPMVRL	Insomnia	7A00-7A0Z	Approved	[2]
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1 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,2-diamino cyclopentane-based derivative 28	DMUTF17	N. A.	N. A.	Patented	[1]
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References

1	Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15.
2	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 214985.