Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9INHD)

• DTT Name: Creatine kinase (CK)
• Synonyms: Creatine kinase
• Gene Name: CKB
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Kinase
• UniProt ID: KCRB_HUMAN ; KCRS_HUMAN ; KCRU_HUMAN ; KCRM_HUMAN
• TTD ID: T98090
• Sequence:
  MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLDDVIQTG
  VDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSDEHKTDLNPDNLQGGDD
  LDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMT
  EAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISM
  QKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLP
  NLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLL
  IEMEQRLEQGQAIDDLMPAQK
• Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
• KEGG Pathway:
  Arginine and proline metabolism (hsa00330)
  Metabolic pathways (hsa01100)
• Reactome Pathway:
  RND3 GTPase cycle (R-HSA-9696264)
  Creatine metabolism (R-HSA-71288)
• BioCyc Pathway: MetaCyc:HS09344-MON

Molecular Interaction Atlas (MIA) of This DTT

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5-(4'-benzoylbiphenyl-4-yl)-2-furoic acid	DM6KSN9	Discovery agent	N.A.	Investigative	[2]
Iodoacetamide	DMM4XVL	Discovery agent	N.A.	Investigative	[1]

References

• [1] Creatine kinase inhibitor iodoacetamide antagonizes calcium-stimulated inotropy in cardiomyocytes. Clin Exp Pharmacol Physiol. 2009 Feb;36(2):141-5.
• [2] NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction proximate to the ATP binding s... J Med Chem. 2007 Apr 19;50(8):1865-75.