Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9JBY5)

DTT Name	N-myc proto-oncogene protein (MYCN)
Synonyms	bHLHe37; NMYC; N-myc; Class E basic helix-loop-helix protein 37
Gene Name	MYCN
DTT Type	Literature-reported target	[1]
UniProt ID	MYCN_HUMAN
TTD ID	T88786
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPP LSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGF SAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELA HPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPG GRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTIT VRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLK SVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKV VILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
Function	Positively regulates the transcription of MYCNOS in neuroblastoma cells.
KEGG Pathway	Transcriptional misregulation in cancer (hsa05202 )
Reactome Pathway	Signaling by ALK (R-HSA-201556 )

References

1	Where pathology meets molecular biology: N-myc amplification in human neuroblastoma as a paradigm for the clinical use of an oncogene alteration. Verh Dtsch Ges Pathol. 1994;78:26-33.