Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9JL72)

DTT Name	PRKAR1A messenger RNA (PRKAR1A mRNA)
Synonyms	cAMP-dependent protein kinase type I-alpha regulatory subunit (mRNA); Tissue-specific extinguisher-1 (mRNA); Tissue-specific extinguisher 1 (mRNA); TSE1 (mRNA); RIalpha subunit of cAMP-dependent protein kinase (mRNA); PRKAR1 (mRNA); PKR1 (mRNA); PKA RIalpha-subunit (mRNA); CAMP-dependent protein kinase (PKA) (mRNA)
Gene Name	PRKAR1A
DTT Type	Literature-reported target	[1]
BioChemical Class	mRNA target
UniProt ID	KAP0_HUMAN
TTD ID	T36651
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG PCSDILKRNIQQYNSFVSLSV
Function	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
KEGG Pathway	Insulin signaling pathway (hsa04910 )
Reactome Pathway	PKA activation in glucagon signalling (R-HSA-164378 ) DARPP-32 events (R-HSA-180024 ) Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (R-HSA-381676 ) Vasopressin regulates renal water homeostasis via Aquaporins (R-HSA-432040 ) CREB1 phosphorylation through the activation of Adenylate Cyclase (R-HSA-442720 ) Hedgehog 'off' state (R-HSA-5610787 ) GPER1 signaling (R-HSA-9634597 ) ADORA2B mediated anti-inflammatory cytokines production (R-HSA-9660821 ) FCGR3A-mediated IL10 synthesis (R-HSA-9664323 ) ALK mutants bind TKIs (R-HSA-9700645 ) Signaling by ALK fusions and activated point mutants (R-HSA-9725370 ) Factors involved in megakaryocyte development and platelet production (R-HSA-983231 ) PKA activation (R-HSA-163615 )

References

1	Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-direct... Clin Cancer Res. 2000 Sep;6(9):3434-41.