Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9JZPU)

• DTT Name: Pediculus humanus Nicotinic acetylcholine receptor (Pedhc nAChR)
• Synonyms: Acetylcholine receptor protein alpha 1, 2, 3, 4invertebrate, putative; Acetylcholine receptor protein alpha 1, 2, 3, 4 invertebrate, putative
• Gene Name: Pedhc nAChR
• DTT Type: Successful target; [1]
• UniProt ID: E0VDF4_PEDHC
• TTD ID: T63598
• Sequence:
  MCLCLCLTPFLDIPGFKPVQMEANPDAKRLYDDLLSNYNRLIRPVVNNTETLTVRLGLKL
  SQLIEVNLKSQVMTTNVWVEQKWTDYKLRWNPEEYGGVEMLYVPSEHIWLPDIVLYNNAD
  GNYEVTLMTKATLNYNGEVYWKPPAIYKSSCEINVLYFPFDEQSCYMKFGSWTYHGYQVD
  LKHMDQKPGTNLVPVGVDLKEFYLSVEWDILEVPARKNEEYYPCCAEPYSDITFNLKMRR
  KTLFYTVNLIIPCVGITFLTVLVFYLPSDSGEKVTLTVSILLSLTVFFLLLAEIIPPTSL
  AVPLLGKYLLFTMMLVTLSIFITVCVLNIYFRSPSTHKMSPWVRNVFLNFIPRLLMMRRP
  PYSVRRDGYDDSGDNGYASALDYRDGIGEPFPPELKGSPEFESVTTVCKSTFGTESDDNL
  GTTFRHAQPSDSENIIPRNLSSDVLSALQGVCFIAQHIRNADKDNEVIEDWKYVSMVLDR
  FFLWVFTLACIGGTCAIIFQAPSLYDQRIPIDQEISLIQFGKIFLNIPREQNSD
• Function: Mediates the fast actions ofacetylcholine (ACh) in the nervous system and at neuromuscular junctions.

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spinosad	DM0BQRS	Head and body lice	1G00.0	Approved	[1]

References

• [1] 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.