Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9TQRP)

DTT Name	Uridine phosphorylase (UPP)
Synonyms	UrdPase; UPase
Gene Name	UPP1
DTT Type	Literature-reported target	[1]
BioChemical Class	Pentosyltransferase
UniProt ID	UPP1_HUMAN ; UPP2_HUMAN
TTD ID	T97388
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS YFIKKKLSKA
Function	Catalyzes the reversible phosphorylytic cleavage ofuridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
KEGG Pathway	Pyrimidine metabolism (hsa00240 ) Drug metabolism - other enzymes (hsa00983 ) Metabolic pathways (hsa01100 ) Nucleotide metabolism (hsa01232 )
Reactome Pathway	Pyrimidine catabolism (R-HSA-73621 ) Pyrimidine salvage (R-HSA-73614 )
BioCyc Pathway	MetaCyc:HS00053-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

1 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TK-112690	DMKV52P	Mucositis	CA00	Investigative	[1]
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References

1	CN patent application no. 102014919, Methotrexate adjuvants to reduce toxicity and methods for using the same.